Journal of Cell Regeneration and Medicine: Is a peer-reviewed journal that aims to publish reliable information about regeneration with the mode of different types of articles like research papers. It covers all the topics related to cell regeneration.
Journal of Cell Regeneration and Medicine mainly focuses on:
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- Cell biology: The Study of Cell Structure and Function.
Cell biology can be divided into four parts.
1. Cell metabolism study
2. Cell Communication Study.
3. Cell cycle study.
4. Cell composition study. - Cardiovascular tissue: Cardiovascular tissue: They play an important role in circulating blood to transport blood cells, nutrients, carbon dioxide, and oxygen to maintain the balance of the human body.
- Progenitor cells: They are biological cells that can differentiate into a specific cell type. These include specialized cells (neutrophils) and specialized cells ( red blood cells).Progenitor cells, sometimes called lymphocytes, are small, round cells measuring 3–8 μm in diameter, characterized by a disproportionately large nucleus and a lack of cytoplasmic extensions. In live preparations, the nucleus can be so prominent that it may be difficult to distinguish the boundary between the nucleus and the cytoplasm. This type of cell is among the most commonly observed in Holothuroidea. However, the physiological role of progenitor cells remains a subject of ongoing debate.
- Skeletal muscle stem cell:They are highly elongated cells with a very elastic and resistant plasma membrane. Skeletal muscle has a remarkable ability to regenerate after acute injury, thanks in part to a population of resident adult muscle stem cells known as ‘satellite cells,’ named for their anatomical position between the myofiber and the basal lamina. Because skeletal muscle frequently experiences injury from weight-bearing, exercise, and trauma, it requires a constantly available and renewable source of cells for repair and regeneration. Since their discovery, satellite cells have been recognized as a prime candidate for the role of adult skeletal muscle “stem cells.” Positioned in a dormant state beneath the basal lamina of mature skeletal muscle fibers, these cells are ideally situated to facilitate the timely repair of damaged muscle tissue.
- Regenerative medicine: They focused on developing new treatments to heal tissues and organs and restore function loss due to disease, damage, defects, or aging. Regenerative medicine is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. This field offers the potential to repair damaged tissues and organs by either replacing the injured tissue or activating the body’s natural repair mechanisms. Additionally, regenerative medicine may allow scientists to grow tissues and organs in the lab and safely implant them when the body is unable to heal itself.
- Mesenchymal stem cell: Mesenchymal stem cells (MSCs) are a diverse group of multipotent cells believed to be located within the connective mesenchyme or around blood vessels in most adult tissues. These cells, also known as mesenchymal stromal cells, play a significant role in both preclinical and clinical research. The first therapeutic use of MSCs was tested in 1995, and since then, over 1,300 clinical trials involving MSCs have been registered on clinicaltrials.gov.
- Mode of regeneration: Regeneration is a process in which, if an organism is divided into multiple parts, each section can regrow into its original form.This process is facilitated by specialized cells known as stem cells. Regeneration typically occurs in organisms with a simple structure and a limited number of specialized cells. There are three primary types of regeneration:
- 1. Epimorphosis: Involves the regeneration of a lost or damaged part of the organism. This type of regeneration begins with the proliferation of new cells on the surface of the injured area. Initially, the adult structures at the injury site undergo dedifferentiation, then proliferate to increase the number of dedifferentiated cells, forming a structure known as the blastema. The blastema grows and develops into the missing structures. Cells within the blastema redifferentiate to create the rudiments of the lost part. Examples: include limb regeneration in salamanders and tail regeneration in lizards.
- 2. Morphallaxis: Regeneration occurs primarily through the reorganization of existing tissues with minimal new growth. In this type of regeneration, each part of the organism is remolded to form a completely new organism. Example: When a Hydra is cut into smaller pieces, each segment containing specialized interstitial cells can grow into a fully formed organism.
- 3. Compensatory Regeneration: This type of regeneration happens when a part of an organ is damaged, and the organ regenerates by the proliferation of existing tissue. In this process, the cells divide without undergoing dedifferentiation. The newly produced cells are similar to the original ones but do not form a mass of undifferentiated tissue. Example: Regeneration in the mammalian liver.
- Cancer stem cell: The term “cancer stem cell” (CSC) refers to a small subset of cells within a solid tumor that can self-renew uncontrollably, leading to ongoing tumor growth and the creation of partially differentiated progenitor cells. According to the stem cell hypothesis of cancer, CSCs undergo asymmetric mitosis, producing both a malignant stem cell and a progenitor cell. Most cells within the tumor—comprising the phenotypically diverse population characteristic of a specific cancer type—arise from the differentiation of progenitor cells and are only weakly tumorigenic. Identifying CSCs requires assessing a cell’s multipotency, or its ability to produce functional, differentiated offspring, alongside its capacity for continued self-renewal. CSCs have been identified in several types of cancer, including those of the blood, brain, skin, breast, ovaries, and prostate.
- Metamorphosis
- Artificial organs
- Stem cells and cloning
- Regenerative medicine
- Stem cell treatment
- Stem cell and cloning
